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Sabtu, 31 Januari 2009

New Diabetes, Weight Loss Drug?

Chinese researchers may have found the key to an oral drug that could treat both type 2 diabetes and obesity.
They are focusing on a compound called Boc5 by Ming-Wei Wang, MD, PhD, and colleagues at the National Center for Drug Screening and the Chinese Academy of Sciences in Shanghai, China.
Boc5 is not powerful enough to become a diabetes or weight loss drug. But Wang and colleagues suggest that daughter compounds could join the latest generation of diabetes drugs, called "incretin mimetics."
The drugs help people with type 2 diabetes normalize their blood sugar, lose weight, and perhaps even gain new insulin-making cells.
To find Boc5, Wang and colleagues screened 48,160 compounds for GLP-1-like activity. Eventually, these compounds led them to the molecule now called Boc5.
The scientists tested the Boc5 drugs in a strain of mice bred with a defect that makes them overeat. "Although the observed effects point to a potential anti-diabetic, anti-obesity utility, a practical drug will likely require greater potency," Wang and colleagues conclude.

Helping Obese Diabetics Lose Weight

Helping obese diabetics lose weight

A plate and cereal bowl with markers for proper portion sizes appear to help obese patients with diabetes lose weight and decrease their use of glucose-controlling medications, according to a report in the June 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Between 1960 and 2000, the proportion of U.S. adults who were obese increased from 13.4 percent to 30.9 percent, according to background information in the article. Most cases of type 2 diabetes can be attributed directly to obesity. Restricting calories has been shown to improve blood sugar control in diabetics, partially by contributing to weight loss. The increasing prevalence of obesity is paralleled by increasing portion sizes in the marketplace, the authors write. Portion sizes are an important determinant of energy intake; the number of calories ingested by subjects at a meal has been directly correlated with the serving size offered.

Sue D. Pedersen, M.D., F.R.C.P.C., and colleagues at the University of Calgary, Alberta, Canada, conducted a six-month controlled trial of commercially available portion control plates and bowls in 2004. The plates were divided into sections for carbohydrates, proteins, cheese and sauce, with the rest left open for vegetables. The sections approximately totaled an 800-calorie meal for men and a 650-calorie meal for women. The cereal bowl is designed to allow a 200-calorie meal of cereal and milk. Half of 130 obese patients with diabetes (average age 56) were randomly assigned to use the plate for their largest meal and the bowl when they ate cereal for breakfast. The other half of the participants received usual care, which consisted of dietary assessment and teaching by dieticians.

At the end of the six-month follow-up, 122 patients remained in the study. Individuals using the portion-control dishes lost an average of 1.8 percent of their body weight, while those receiving usual care lost an average of 0.1 percent. A significantly larger proportion of those using the dishes16.9 percent vs. 4.6 percentlost at least 5 percent of their body weight. This is important, as a 5 percent weight loss has been shown to be clinically significant in terms of decreasing morbidity and mortality associated with obesity-linked disorders such as cancer and myocardial infarction [heart attack], the authors write.

In addition, more of those in the intervention group vs. the regular care group experienced a decrease in their use of diabetes medications after six months (26.2 percent vs. 10.8 percent).

In conclusion, the portion control tool studied in this trial was effective in inducing weight loss in obese persons with type 2 diabetes mellitus comparable to that seen in investigations of weight loss pharmacotherapy, the authors write. This simple, inexpensive tool also enabled obese patients with diabetes mellitus to decrease their hypoglycemic medicine requirements. This intervention holds promise for use in overweight populations with and without diabetes mellitus.

Jumat, 30 Januari 2009

Cook For Diabetes

One of the tools for managing Type 2 diabetes is a healthy diet. But staying on that diet can be hard if you eat at restaurants a lot. Cooking at home can really help you control your calories, carbs and fat grams. And now that the economy is faltering, it's also wise to eat at home, just to save money.

So, cooking can be a win-win if you have diabetes. But what if you're not especially talented in the kitchen? Need skills? Need recipes? The guides can help.

Learning to cook? Get the skills.

Healthy recipes to get you started.

More from your diabetes guide...

The Health Guides at can help you take control of what you eat and how much you spend. Armed with a little kitchen savvy and some great recipes, you can master cooking at home, which will help your health and your wallet.

Rabu, 14 Januari 2009

Yuummy juicyy,,

Juice Recipe for Diabetes (Type 2)

This juice improves high blood sugar and high blood pressure.

Diabetes is a disease in which the body does not produce or properly use insulin. Cucumber lowers blood sugar (glucose) and blood pressure. Swiss chard has phytochemicals similar with insulin so it helps lower blood sugar and remove fatigue. Clove powder can lower blood sugar, triglyceride and cholesterol. Fenugreek powder helps balance blood sugar in diabetes and aids to lower cholesterol.

Diabetes Type 2 is usually caused by wheat powder products and fried food. Drink 4 to 6 cups of this juice everyday and stay away from noodle, bread, cake, dessert and BBQ food.


  • 1/2 beetroot, peeled and sectioned
  • 1 carrot
  • 1 cucumber, sectioned
  • some swiss chard
  • 1 corn (grain)
  • 1 tomato
  • 1 lemon, peeled


  • 3 teaspoons flaxseed
  • 1/3 teaspoon cinnamon powder (or fenugreek powder)
  • 1/3 teaspoon clove powder
  • 2 teaspoons of bee pollen


  • some wolfberry (lycium barbarum)
  • ginger

Process through a juicer and serve. It is even better if you use distilled water.

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Pills of Diabetics Oral

Diabetics group are grouped in categories based on type. There are several categories of diabetes pills -- each works differently.

  • Sulfonylureas. These diabetes pills lower blood sugar by stimulating the pancreas to release more insulin. The first drugs of this type that were developed -- Dymelor, Diabinese, Orinase and Tolinase -- are not as widely used since they tend to be less potent and shorter-acting drugs than the newer sulfonylureas. They include Glucotrol, Glucotrol XL, DiaBeta, Micronase, Glynase PresTab, and Amaryl. These drugs can cause a decrease in the hemoglobin A1c ( HbA1c) of up to 1%-2%.
  • Biguanides. These diabetes pills improve insulin's ability to move sugar into cells especially into the muscle cells. They also prevent the liver from releasing stored sugar. Biguanides should not be used in people who have kidney damage or heart failure because of the risk of precipitating a severe build up of acid (called lactic acidosis) in these patients. Biguanides can decrease the HbA1c 1%-2%. An example includes metformin (Glucophage, Glucophage XR, Riomet, Fortamet and Glumetza).
  • Thiazolidinediones. These diabetes pills improve insulin's effectiveness (improving insulin resistance) in muscle and in fat tissue. They lower the amount of sugar released by the liver and make fat cells more sensitive to the effects of insulin. Actos and Avandia are the two drugs of this class. A decrease in the HbA1c of 1%-2% can be seen with this class of oral diabetes medications. These drugs may take a few weeks before they have an effect in lowering blood sugar. They should be used with caution in people with heart failure. Your doctor will do periodic blood testing of your liver function when using this diabetes medicine.
  • Alpha-glucosidase inhibitors, including Precose and Glyset. These drugs block enzymes that help digest starches, slowing the rise in blood sugar. These diabetes pills may cause diarrhea or gas. They can lower hemoglobin A1c by 0.5%-1%.
  • Meglitinides, including Prandin and Starlix. These diabetes medicines lower blood sugar by stimulating the pancreas to release more insulin. The effects of these diabetes pills depend on the level of glucose. They are said to be glucose dependent. High sugars make this class of diabetes medicines release insulin. This is unlike the sulfonylureas that cause an increase in insulin release, regardless of glucose levels, and can lead to hypoglycemia.
  • Dipeptidyl peptidase IV (DPP-IV) inhibitors, including Januvia. The DPP-IV inhibitors (Januvia) work to lower blood sugar in patients with type 2 diabetes by increasing insulin secretion from the pancreas and reducing sugar production. These diabetes pills increase insulin secretion when blood sugars are high. They also signal the liver to stop producing excess amounts of sugar. DPP-IV inhibitors control sugar without causing weight gain. The medication may be taken alone or with other medications such as metformin.
  • Combination therapy. There are several combination diabetes pills that combine two medications into one tablet. One example of this is Glucovance, which combines glyburide (a sulfonylurea) and metformin. Others include Metaglip, which combines glipizide (a sulfonylurea) and metformin, and Avandamet which utilizes both metformin and rosiglitazone (Avandia) in one pill.
Studies have been done showing that some diabetes pills may help prevent diabetes and diabetes-related complications. Both metformin and Precose have been shown to reduce a person's risk of developing type 2 diabetes, particularly when combined with lifestyle changes such as a proper diet and regular exercise program. Actos has been shown to reduce the risk of heart attack, stroke, and premature death in those with type 2 diabetes.

This Original Site can u link from

Minggu, 11 Januari 2009

Diet Holiday

In time for the holidays, TJ Dietderich has sent me a link to Jeannie Baellow's video blog. In this post, she discusses her plans for keeping on track with her new diet during the holiday season: An Easy Meal Plan For The Holidays. Jeannie is the winner of the Diabetes Challenge, which means she's receiving training and counseling from the Lifestyle Center of America to help control her diabetes and video blogging about the experience. Hopefully you dear readers will learn a lesson or two on holiday dieting from Jeannie.

Tips For a Good Medical Diabetics Treatment

Are you still looking for an endocrinologist? Here are some tips from Lyle Mitzner, M.D., at Joslin Diabetes Center to make the whole process a LOT easier:
  • Check with your insurance company first to see which physicians it covers.
  • Know the right places to look. Do research on these places to narrow your search down.
  • Ask family and friends or check with a local hospital for recommendations.
  • If you're going to an academic center, make sure the endocrinologist has a particular interest in your condition, as many doctors in academic centers are specialized to the point that they only see thyroid, diabetes or pituitary disorders, according to Mitzner.
  • Don't be afraid to ask questions to make sure it's the right fit.
  • Check out their credentials: where did they go to medical school, are they specialized in the right area, is he or she board certified, where did they complete their fellowship program?
  • Make sure they are someone you can trust, communicate well with and establish a long-term relationship with. During the first visit, inform them of the details of your lifestyle and health history to make sure they suit your needs.
Source: Joslin Diabetes Center

Elevated Blood Sugar and Cognitive Decline

Researchers at the Columbia University Medical Center reported that high blood sugar levels is linked to normal cognitive aging. As we grow older, our blood sugar levels increase (even if we do not have type 2 diabetes) and this contributes to cognitive decline. According to lead investigator Scott A. Small, M.D., associate professor of neurology in the Sergievsky Center and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center:
"This is news even for people without diabetes since blood glucose levels tend to rise as we grow older. Whether through physical exercise, diet or drugs, our research suggests that improving glucose metabolism could help some of us avert the cognitive slide that occurs in many of us as we age."

Sabtu, 10 Januari 2009

Physical Activities and two type of diabetics

The findings that increasing physical activity and limiting television may lead to reduction in type 2 diabetes isn't exactly new. The focus on the research by Boston University's Slone Epidemiology Center are African-American women - which make up a significant percentage of the population in the United States affected by type 2 diabetes.

Using data collected through questionnaires in the Black Women's Health Study, (an ongoing prospective follow-up study of African-American women from across the U.S.), the researchers found that vigorous activity was inversely associated with a reduced risk of diabetes. Brisk walking (for five plus hours/week) was also associated with a reduced risk of diabetes, as compared to no walking.

Television watching was positively associated with an increased risk of diabetes. The researchers found the risk of type 2 diabetes was increased among women who spent an appreciable amount of time watching television. This increase was apparent whether or not a woman was physical active.

Well even without type 2 diabetes, the increased physical activity and less tv will do us all good.

Jumat, 09 Januari 2009

Is food combining important for weight loss?

Books and programs on food combining have been on and off the best-seller lists for years. They should be in the fiction section. The authors claim that eating protein and carbohydrates, or fat and carbohydrates together causes problems because they require different enzymes for digestion, and either acid or alkaline conditions.

They give you elaborate lists of foods that you can or cannot eat at the same meal. If any of this were true, the human race would be extinct. Few foods are “pure” protein, carbohydrate or fat. Your digestive system has evolved to deal with mixed foods, and the enzymes secreted by your pancreas can digest them all in any combination.

Your stomach is strongly acidic, no matter what food you eat. Stomach acid is much stronger than lemon juice, tomatoes or any other acid food. Nothing you eat escapes this acid “soup” while it is in your stomach, so it makes no difference whether you combine acid and alkaline foods.

These authors tell you that the undigested food will ferment and putrify, causing you to accumulate toxins in your intestines. This just doesn’t happen. Your intestines do a very efficient job of breaking down carbohydrates, fats and proteins into their building blocks, which are then absorbed into your bloodstream.

As long as you are not constantly constipated, your colon does an excellent job of removing the waste products of digestion. If you have a problem with constipation, the answer lies not which foods you combine, but in adding fiber and water to your diet.

They even claim that the undigested food makes you fat, which is impossible. To be stored as fat, a food must be broken down into its building blocks and pass from the intestines into the bloodstream. Any undigested food would be excreted, making you thinner, not fatter.

People who lose weight following these nonsensical rules do so simply because they are forced to limit their food choices and therefore consume fewer calories.

Do not confuse these ridiculous diets with serious “combination” recommendations that are made in two special situations:

Diabetics and others who are concerned about sharp rises in blood sugar are advised to eat fruits and root vegetables only in combination with other foods. Fruits and root vegetables contain lots of sugar or quickly digested starches which can cause blood sugar to rise after eating.

However, a healthy diet does not eliminate these foods because they also contain lots of vitamins, minerals and other phytochemicals that your body uses to keep you healthy and prevent diseases. When you eat these foods WITH other foods, particularly proteins or fats, they are digested more slowly. Diabetics should include a variety of fruits and root vegetables in their diet, but eat them with meals, not alone.

Strict Vegetarians who eat no animal products are often advised to COMBINE beans and grains so they will get complete proteins. This is true, but you do not need to eat the foods together at the same meal. The proteins found in meat and dairy products contain all nine essential amino acids (the ones your body needs and cannot make), and so they are called complete proteins.

Most plant sources of protein, such as beans and grains, contain only two to seven of the essential amino acids, so you must eat a variety of these foods to assure that you get them all. However, you can do this over the course of the day or week. Amino acids circulate constantly in your bloodstream and are used as needed. You do not need to eat the foods simultaneously to supply your body with the different amino acids you need.

***Note: We encourage EVERYONE to see a doctor before altering their diet, taking a supplement and/or performing athletic, fitness or other strenuous physical activity. It is your responsibility to evaluate the accuracy, completeness and usefulness of any information, instruction, opinion or advice contained in the content. Please also see our complete disclaimer.***

This post is written by Dr. Gabe Mirkin, M.D. and was originally published on his blog “Fitness and Health E-Zine”.

Dr. Mirkin is board certified in Sports Medicine and has practiced for over 40 years. He has completed more than 40 marathons and was a talk show host of a nationally-syndicated radio program for about 25 years. For more articles by Dr. Mirkin, please check out:

Please also be advised that Dr. Mirkin’s opinions and the references cited are for information only, and are not intended to diagnose or prescribe. For your specific diagnosis and treatment, consult your doctor or health care provider.

Sabtu, 03 Januari 2009

Do You Know about your illness??

hi..everyone.. This is my first blog. I would tell you about some dangerous illness that can happened to your body, but don't worry, i will give you the way to solve your problem. So always check this blog out.